Natural history of cerebral dot-like cavernomas.
Clin Radiol
; 68(8): e453-9, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23663874
ABSTRACT
AIM:
To elucidate the natural history of dot-like or "black spot" cavernomas. MATERIALS ANDMETHODS:
Data of 18 children with black spot cavernomas were analysed retrospectively.RESULTS:
Eleven boys and seven girls presented 187 black spot cavernomas during a mean observation period of 5.5 years. Mean and median age at diagnosis of the 187 cavernomas was 9.6 years. There were 70 de novo black spot cavernomas. Boys presented significantly more cavernomas than girls. There were three KRIT1 mutation carriers and four PDCD 10 mutation carriers. Children with a PDCD 10 mutation presented significantly more lesions than those children with a KRIT1 mutation (mean number of lesions per patient 23.3 versus 3.3, respectively). There were 10 radiological haemorrhagic events caused by 10 black spot lesions. Two of these events were symptomatic. The haemorrhage rate of black spot cavernomas was 0.7% per lesion-year.CONCLUSIONS:
A mean bleeding rate of 0.7% per lesion-year is lower than the overall haemorrhage rates provided in the literature. Nonetheless, black spot cavernomas are not purely benign lesions. Furthermore, genetic mutations may play a role in the natural history of black spot cavernomas.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Hemangioma Cavernoso do Sistema Nervoso Central
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Clin Radiol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Alemanha