GPER-1 expression decreases during breast cancer tumorigenesis.
Cancer Invest
; 31(5): 309-15, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23688258
GPER-1 protein expression was immunohistochemically examined in 164 primary breast cancer specimens and their matched normal breast epithelium. GPER-1 down-regulation correlated significantly with increased histological grading (p = .015), lymph node metastases (p = .032), and negative estrogen receptor status (p = .018). The decrease of GPER-1 expression in breast cancer tissue, relative to normal tissue, was associated with poor overall survival (p = .043) and disease-free survival (p = .037) and remained a significant unfavorable factor in multivariate analysis for DFS (HR = 1.569; 95% CI, 1.024-2.797; p = .041) and OS (HR = 2.082; 95% CI, 1.248-4.773; p = .039). Thus aberrant GPER-1 expression seems to be an important factor in breast cancer progression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Receptores de Estrogênio
/
Transformação Celular Neoplásica
/
Carcinoma Ductal de Mama
/
Carcinoma Intraductal não Infiltrante
/
Receptores Acoplados a Proteínas G
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Cancer Invest
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Alemanha