Fluorescence in situ hybridization (FISH) as an aid for the diagnosis of graft-versus-host disease in two multivisceral organ transplant patients.
Am J Dermatopathol
; 35(4): 496-502, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23694825
ABSTRACT
We herein describe 2 cases of adult multivisceral transplant patients who developed graft-versus-host disease manifesting predominantly as lichenoid skin papules and plaques. The diagnosis was supported by histopathology but ultimately corroborated by the utilization of the fluorescence in situ hybridization (FISH) technique using X and Y chromosome probes on unstained biopsy slides. In both cases, FISH revealed a high percentage of donor-derived cells as part of the inflammatory infiltrate in the skin biopsy. This report adds to the previous publications showing the utility of FISH in corroborating the diagnosis of graft-versus-host disease in transplant patients with unmatched sex donor.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testes Genéticos
/
Transplante de Órgãos
/
Hibridização in Situ Fluorescente
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Cromossomos Humanos X
/
Cromossomos Humanos Y
/
Doença Enxerto-Hospedeiro
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Dermatopathol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos