[Expression and clinical significance of circadian gene Per2 in non-small cell lung cancer].

ABSTRACT

OBJECTIVE: To detect the expression of Per2 in non-small cell lung cancer (NSCLC), and analyze its clinical significance. METHODS: The expression of Per2 was determined in 60 NSCLC and 20 normal lung tissues by immunohistochemical assay, and the relationship between Per2 expression and clinicopathological features was analyzed. RESULTS: The positive expression rates of Per2 in NSCLC and normal lung tissues were 71.7% and 95.0%, respectively (P < 0.05). The expression of Per2 in NSCLC was correlated with pathological differentiation and TNM stage (P < 0.05). CONCLUSION: The expression of Per2 in NSCLC is decreased. The negative expression of Per2 may contribute to the development and invasion in NSCLC.