[Expression and clinical significance of circadian gene Per2 in non-small cell lung cancer].
Zhonghua Zhong Liu Za Zhi
; 35(2): 129-31, 2013 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-23714668
ABSTRACT
OBJECTIVE:
To detect the expression of Per2 in non-small cell lung cancer (NSCLC), and analyze its clinical significance.METHODS:
The expression of Per2 was determined in 60 NSCLC and 20 normal lung tissues by immunohistochemical assay, and the relationship between Per2 expression and clinicopathological features was analyzed.RESULTS:
The positive expression rates of Per2 in NSCLC and normal lung tissues were 71.7% and 95.0%, respectively (P < 0.05). The expression of Per2 in NSCLC was correlated with pathological differentiation and TNM stage (P < 0.05).CONCLUSION:
The expression of Per2 in NSCLC is decreased. The negative expression of Per2 may contribute to the development and invasion in NSCLC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
/
Proteínas Circadianas Period
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Neoplasias Pulmonares
Limite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Zhong Liu Za Zhi
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China