Endothelin-1-induced endoplasmic reticulum stress in disease.
J Pharmacol Exp Ther
; 346(2): 163-72, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23740603
ABSTRACT
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a cellular stress induced by multiple stimuli and pathologic conditions. Recent evidence implicates endothelin-1 (ET-1) in the induction of placental ER stress in pregnancy disorders. ER stress has previously also been implicated in various other disease states, including neurodegenerative disorders, diabetes, and cardiovascular diseases, as has ET-1 in the pathophysiology of these conditions. However, to date, there has been no investigation of the link between ET-1 and the induction of ER stress in these disease states. Based on recent evidence and mechanistic insight into the role of ET-1 in the induction of placental ER stress, the following review attempts to outline the broader implications of ET-1-induced ER stress, as well as strategies for therapeutic intervention based around ET-1.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença
/
Endotelina-1
/
Estresse do Retículo Endoplasmático
Tipo de estudo:
Etiology_studies
Limite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
J Pharmacol Exp Ther
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Suíça