Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis.
Eur J Pharmacol
; 715(1-3): 72-5, 2013 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-23810684
Endometriosis is one of the most frequent gynecological diseases. In addition to their side effects, available medical therapies may decrease fertility. Current understanding of endometriosis focuses on the role of the immune system in its pathophysiology. Recent research shed light on the immunomodulatory effect of vitamin D3. Thus, this study was designed to study the effect of vitamin D3 on regression of endometriotic implants in a rat surgical model. Vitamin D3 reduced cyst cross sectional area by 48.8%. Histologically, vitamin D treatment produced fibrosis as well as apoptosis in the stroma. The results of the present study suggest that vitamin D3 administration may have a beneficial effect in treating endometriosis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colecalciferol
/
Endometriose
/
Endométrio
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Jordânia