Automated QuantMap for rapid quantitative molecular network topology analysis.
Bioinformatics
; 29(18): 2369-70, 2013 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-23828784
ABSTRACT
SUMMARY:
The previously disclosed QuantMap method for grouping chemicals by biological activity used online services for much of the data gathering and some of the numerical analysis. The present work attempts to streamline this process by using local copies of the databases and in-house analysis. Using computational methods similar or identical to those used in the previous work, a qualitatively equivalent result was found in just a few seconds on the same dataset (collection of 18 drugs). We use the user-friendly Galaxy framework to enable users to analyze their own datasets. Hopefully, this will make the QuantMap method more practical and accessible and help achieve its goals to provide substantial assistance to drug repositioning, pharmacology evaluation and toxicology risk assessment.AVAILABILITY:
http//galaxy.predpharmtox.org CONTACT mats.gustafsson@medsci.uu.se or ola.spjuth@farmbio.uu.se SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
/
Preparações Farmacêuticas
/
Mapeamento de Interação de Proteínas
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Suécia