How should we approach classification of autoinflammatory diseases?
Nat Rev Rheumatol
; 9(10): 624-9, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23838615
ABSTRACT
The notion of 'autoinflammatory' disease was introduced at the end of the 1990s, and, since then, this concept has rapidly evolved. As a result, multiple definitions of autoinflammatory disease, and classifications of conditions encompassed by these definitions, have been proposed; this succession highlights advances that have been made in understanding of the innate immune system, and especially the roles of IL-1ß and the inflammasome in autoinflammtory conditions. However, the definitions and classifications that have been suggested to date face a number of structure and content issues. We therefore propose another, more clinically-oriented, definition autoinflammatory diseases are diseases with clinical signs of inflammation, associated with elevated levels of acute-phase reactants, which are attributable to dysfunction of the innate immune system, genetically-determined or triggered by an endogenous factor. From this foundation, we propose a clinically-based classification of autoinflammatory diseases, and go on to discuss how immunological diseases as a whole, including autoimmune diseases, can be appropriately located within a continuum only if the classification process is multidimensional. For this purpose, we appeal to the philosophical concepts of family resemblance and signature.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Doenças Reumáticas
/
Doenças Hereditárias Autoinflamatórias
Limite:
Humans
Idioma:
En
Revista:
Nat Rev Rheumatol
Assunto da revista:
REUMATOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article