A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells.
Chem Commun (Camb)
; 49(67): 7442-4, 2013 Aug 28.
Article
em En
| MEDLINE
| ID: mdl-23860596
ABSTRACT
Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage-doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doxorrubicina
/
Carcinoma Hepatocelular
/
Proteínas Arqueais
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Proteínas de Choque Térmico Pequenas
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Methanocaldococcus
/
Neoplasias Hepáticas
/
Antibióticos Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Japão