Teamwork in microtubule motors.
Trends Cell Biol
; 23(11): 575-82, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23877011
ABSTRACT
Diverse cellular processes are driven by the collective force from multiple motor proteins. Disease-causing mutations cause aberrant function of motors, but the impact is observed at a cellular level and beyond, therefore necessitating an understanding of cell mechanics at the level of motor molecules. One way to do this is by measuring the force generated by ensembles of motors in vivo at single-motor resolution. This has been possible for microtubule motor teams that transport intracellular organelles, revealing unexpected differences between collective and single-molecule function. Here we review how the biophysical properties of single motors, and differences therein, may translate into collective motor function during organelle transport and perhaps in other processes outside transport.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Motores Moleculares
/
Microtúbulos
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
2013
Tipo de documento:
Article