Automatic assessment of stent neointimal coverage by intravascular optical coherence tomography.
Eur Heart J Cardiovasc Imaging
; 15(2): 195-200, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-23884965
ABSTRACT
AIMS:
This study aimed to validate automatic intravascular optical coherence tomography (IVOCT) analysis for the evaluation of neointimal coverage in response to stent implantation. METHODS ANDRESULTS:
Fourteen stented segments in common iliac arteries, acquired from a total of seven adult male New Zealand White rabbits, were interrogated in vivo by IVOCT. Durable polymer everolimus-eluting stents (EES; Xience V, Abbott Vascular, Santa Clara, CA, USA) were used exclusively. Comparison with histology was made in a total of 63 pairs of images, where neointimal thickness over corresponding individual stent struts was assessed. A high correlation coefficient (R = 0.85, P < 0.001) was obtained by comparing automatic IVOCT analysis with histology. Moreover, Bland-Altman statistics showed good limits of agreement (LOAs) of ±45 µm, with an average difference of -10 µm. In addition, manual IVOCT assessment presented very similar results when compared with histology (R = 0.83, P < 0.001 and LOA = ±48 µm with an average difference of -8 µm). Therefore, a very high correlation value was found, comparing manual to automatic IVOCT measurements (R = 0.95, P < 0.001) together with good LOAs (±27 µm) and an average difference of -2 µm.CONCLUSION:
The results of the study suggest that automatic IVOCT analysis is a reliable and accurate tool able to speed up current IVOCT analysis procedures. This would potentially allow for a better integration of IVOCT in clinical practice and clinical studies assessing vascular response to stent implantation in a large series of patients.Palavras-chave
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tomografia de Coerência Óptica
/
Stents Farmacológicos
/
Neointima
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Revista:
Eur Heart J Cardiovasc Imaging
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Bélgica