Systems biology of host-mycobiota interactions: dissecting Dectin-1 and Dectin-2 signalling in immune cells with DC-ATLAS.
Immunobiology
; 218(11): 1428-37, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23932568
ABSTRACT
Modelling the networks sustaining the fruitful coexistence between fungi and their mammalian hosts is becoming increasingly important to control emerging fungal pathogens. The C-type lectins Dectin-1 and Dectin-2 are involved in host defense mechanisms against fungal infection driving inflammatory and adaptive immune responses and complement in containing fungal burdens. Recognizing carbohydrate structures in pathogens, their engagement induces maturation of dendritic cells (DCs) into potent immuno-stimulatory cells endowed with the capacity to efficiently prime T cells. Owing to these properties, Dectin-1 and Dectin-2 agonists are currently under investigation as promising adjuvants in vaccination procedures for the treatment of fungal infection. Thus, a detailed understanding of events' cascade specifically triggered in DCs upon engagement is of great interest in translational research. Here, we summarize the current knowledge on Dectin-1 and Dectin-2 signalling in DCs highlighting similarities and differences. Detailed maps are annotated, using the Biological Connection Markup Language (BCML) data model, and stored in DC-ATLAS, a versatile resource for the interpretation of high-throughput data generated perturbing the signalling network of DCs.
Palavras-chave
BCML; BMDCs; BMM; Biological Connection Markup Language; C-type lectin like receptor; C-type lectins; CLR; Cytokines; DCs; Dendritic cells; IL; Immune response; PRR; Signalling pathway; TLR; Toll like receptor; bone marrow dendritic cells; bone marrow derived macrophages; dendritic cells; interleukin; moDCs; monocyte derived dendritic cells; pathogen recognition receptor
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Lectinas Tipo C
/
Interações Hospedeiro-Patógeno
/
Micoses
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Immunobiology
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália