Targeting cyclin-dependent kinases in anti-neoplastic therapy.
Curr Opin Cell Biol
; 25(6): 772-9, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24011867
ABSTRACT
Cell cycle progression is controlled by sequential activation of cyclin-dependent kinases (CDKs), which are often deregulated in cancer. Consequently numerous pharmacological inhibitors of CDKs have been developed with the aim of treating cancers. The article briefly reviews CDK inhibitors and their use to treat cancers, with specific focus on the use of biomarkers and drugs combination to improve their therapeutic efficacy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinases Ciclina-Dependentes
/
Inibidores de Proteínas Quinases
/
Neoplasias
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
França