Combined hepatocellular-cholangiocarcinoma producing parathyroid hormone-related protein: report of a case.
Surg Today
; 44(8): 1577-83, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24013836
ABSTRACT
Combined hepatocellular-cholangiocarcinoma (CHCC) is an uncommon form of primary liver cancer. A 57-year-old man was readmitted to our hospital for treatment of recurrent CHCC, 12 months after central bisegmentectomy and 4 months after limited hepatic resection. Magnetic resonance imaging (MRI) revealed multiple hepatic nodules. Laboratory data showed increased serum levels of α-fetoprotein (AFP), calcium, and parathyroid hormone-related protein (PTH-rP), to 5,571 ng/mL, 17.0 mg/dL, and 16.1 pmol/L, respectively. Palliative mass reduction surgery was indicated by the fact that the hypercalcemia was difficult to manage medically. Thus, we performed lateral segmentectomy with partial resection of segment 7 and the caudate lobe, and microwave coagulation therapy for multiple recurrent CHCC. Thereafter, the serum PTH-rP and AFP levels decreased remarkably and the hypercalcemia was controlled for the next 3 months. He died of disease progression 9 months after the last hepatic surgery. To our knowledge, this is only the second reported case of CHCC producing PTH-rP in the English-language literature.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colangiocarcinoma
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Carcinoma Hepatocelular
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Proteína Relacionada ao Hormônio Paratireóideo
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Neoplasias Hepáticas
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Neoplasias Primárias Múltiplas
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Surg Today
Ano de publicação:
2014
Tipo de documento:
Article