Superficial necrolytic dermatitis in a dog with an insulin-producing pancreatic islet cell carcinoma.
Vet Pathol
; 51(4): 805-8, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24021558
ABSTRACT
A 10-year-old dog presented with convulsive crisis and symmetrical hyperkeratotic cutaneous lesions affecting the abdomen, inguinal area, eyelids, muzzles, both pinnae, and all the paw pads. Hypoglycemia and hyperinsulinemia were the main biochemical findings. A mass 2 cm in diameter was detected within the left pancreatic lobe by ultrasonography. It was surgically removed and histologically and immunohistochemically diagnosed as an insulin-producing pancreatic islet cell carcinoma. The animal was eventually euthanized due to lack of clinical improvement. At necropsy, metastatic nodules were observed in the pancreatic lymph nodes and liver. Histopathological findings of cutaneous lesions were highly suggestive of superficial necrolytic dermatitis and were interpreted as a paraneoplastic syndrome derived from the islet cell carcinoma. To the authors' knowledge, this is the first report of superficial necrolytic dermatitis associated with an insulin-producing pancreatic neuroendocrine carcinoma in dogs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tumores Neuroendócrinos
/
Dermatite
/
Doenças do Cão
/
Insulina
Tipo de estudo:
Etiology_studies
Limite:
Animals
País/Região como assunto:
Europa
Idioma:
En
Revista:
Vet Pathol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Espanha