IgG4-related disease with cutaneous manifestations treated with rituximab: case report and literature review.
Australas J Dermatol
; 55(2): 132-6, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24032760
ABSTRACT
Immunoglobulin type gamma 4 (Ig)G4-related disease (IgG4-RD) is a relatively recently described clinical entity characterised by elevated levels of serum IgG4 and tissue infiltration of IgG4+ plasma cells in various organ systems. Cutaneous involvement is rare but is becoming increasingly appreciated; typically presenting as erythematous papules and/or nodules that are commonly pruritic. We report a case of IgG4-RD presenting with persistent pruritic papules and unilateral parotid swelling. His serum IgG4 level was elevated and a histological examination of his skin biopsies found a lymphoplasmacytic infiltration with an excess of IgG4+ non-clonal plasma cells. The patient was intolerant of oral prednisolone, however complete resolution of the cutaneous lesions was achieved with the anti-CD20 antibody, rituximab.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
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Imunoglobulina G
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Australas J Dermatol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Austrália