[Adverse skin reactions induced by BRAF inhibitors: a systematic review]. / Effets indésirables cutanés des inhibiteurs de BRAF: revue systématique.
Ann Dermatol Venereol
; 140(8-9): 510-20, 2013.
Article
em Fr
| MEDLINE
| ID: mdl-24034635
ABSTRACT
Recent developments and therapeutic use of selective BRAF inhibitors (e.g. dabrafenib and vemurafenib) have significantly improved overall survival and disease-free survival of patients with BRAF V600 mutation-positive metastatic melanoma. Despite their survival benefits, small-molecule inhibitors of BRAF are associated with significant and sometimes severe treatment-related dermatological toxicity. The most common adverse skin reactions include photosensitivity, induced malignant lesions of the skin such as keratoacanthomas, squamous cell carcinoma and new primary melanomas, as well as keratinocyte proliferation and differentiation dysfunctions that can manifest as skin papillomas, hand-foot skin reaction, keratosis pilaris-like rash, acantholytic dyskeratosis and cysts of the milia type. In this article, we describe the clinical and histological features of the cutaneous manifestations induced by vemurafenib and dabrafenib on the basis of our clinical experience and a literature review. The crucial role of dermatologists in patient management is also highlighted.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Sulfonamidas
/
Toxidermias
/
Proteínas Proto-Oncogênicas B-raf
/
Inibidores de Proteínas Quinases
/
Imidazóis
/
Indóis
/
Proteínas de Neoplasias
/
Antineoplásicos
Tipo de estudo:
Etiology_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
Fr
Revista:
Ann Dermatol Venereol
Ano de publicação:
2013
Tipo de documento:
Article