Phospholipase gene expression during Paracoccidioides brasiliensis morphological transition and infection.
Mem Inst Oswaldo Cruz
; 108(6): 808-11, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-24037207
ABSTRACT
Phospholipase is an important virulence factor for pathogenic fungi. In this study, we demonstrate the following (i) the Paracoccidioides brasiliensis pld gene is preferentially expressed in mycelium cells, (ii) the plb1 gene is mostly up-regulated by infection after 6 h of co-infection of MH-S cells or during BALB/c mice lung infection, (iii) during lung infection, plb1, plc and pld gene expression are significantly increased 6-48 h post-infection compared to 56 days after infection, strongly suggesting that phospholipases play a role in the early events of infection, but not during the chronic stages of pulmonary infection by P. brasiliensis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paracoccidioides
/
Paracoccidioidomicose
/
Fosfolipases
/
Macrófagos Alveolares
/
Fatores de Virulência
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Brasil