Your browser doesn't support javascript.
loading
Role of indacaterol and the newer very long-acting ß2-agonists in patients with stable COPD: a review.
Ridolo, Erminia; Montagni, Marcello; Olivieri, Elisa; Riario-Sforza, Gian Galeazzo; Incorvaia, Cristoforo.
Afiliação
  • Ridolo E; Department of Clinical and Experimental Medicine, University of Parma, Parma. erminia.ridolo@unipr.it
Article em En | MEDLINE | ID: mdl-24082783
Bronchodilators are central drugs in the management of patients with chronic obstructive pulmonary disease (COPD). Indacaterol was the first agent of the novel family of very long-acting ß2-agonists to be used as an inhaled bronchodilator for COPD and provides 24-hour therapeutic action, thus allowing once-daily administration. Data from clinical trials show that indacaterol has a bronchodilator effect similar to that of the anticholinergic tiotropium bromide and slightly higher efficacy compared with the long-acting ß2-agonists, salmeterol and formoterol. Moreover, the safety profile is excellent and comparable with that of placebo. Concerning adherence with drug treatment and real-life management in respect to long-acting ß2-agonists, once-daily dosing makes indacaterol more convenient for COPD patients and is likely to enhance patient adherence. Other very long-acting ß2-agonists currently in development include vilanterol, olodaterol, and carmoterol, and these have shown good characteristics for clinical use in the studies reported thus far.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Broncodilatadores / Quinolonas / Doença Pulmonar Obstrutiva Crônica / Agonistas de Receptores Adrenérgicos beta 2 / Indanos / Pulmão Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Int J Chron Obstruct Pulmon Dis Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Broncodilatadores / Quinolonas / Doença Pulmonar Obstrutiva Crônica / Agonistas de Receptores Adrenérgicos beta 2 / Indanos / Pulmão Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Int J Chron Obstruct Pulmon Dis Ano de publicação: 2013 Tipo de documento: Article