Cerebrospinal fluid biomarkers of Alzheimer's disease in Chinese patients: a pilot study.
Am J Alzheimers Dis Other Demen
; 28(8): 769-75, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24085246
In view of the paucity of data on cerebrospinal fluid (CSF) biomarkers in Chinese patients, we evaluated the validity of tau, phosphorylated tau 181 (p-tau-181), amyloid ß 42 (Aß42), and Aß40 proteins in Chinese patients with Alzheimer's disease (AD). We recruited 24 patients with AD, 12 nondemented controls, and 12 patients with non-AD dementia. We found the CSF levels of Aß42, tau, p-tau, Aß42-tau, and Aß42-p-tau ratios, except the Aß40 protein level, were significantly different among the 3 groups of patients. Patients with AD had higher levels of CSF tau and p-tau but lower levels of Aß42 proteins, Aß42-tau, and Aß42-p-tau ratios than the nondemented controls. In the diagnosis of AD versus nondementia, the sensitivity and specificity of the ratios of Aß42-tau and Aß42-p-tau were 96% and 83% versus 92% and 83%, respectively. Only the Aß42-p-tau ratio showed satisfactory sensitivity and specificity in the diagnosis of AD versus other dementia.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Peptídeos beta-Amiloides
/
Proteínas tau
/
Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Alzheimers Dis Other Demen
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Hong Kong