Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones.
Science
; 228(4707): 1540-3, 1985 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-2409597
ABSTRACT
A series of clones of human natural killer (NK) cells was characterized with respect to expression of the Ti alpha and Ti beta genes of the T-cell receptor. T11+T3+ NK clones contained Ti alpha and Ti beta RNA transcripts and expressed disulfide-linked heterodimers, demonstrating the presence of a functional T-cell receptor. In contrast, T11+T3- NK clones expressed only 1.0-kilobase truncated Ti beta transcripts, without a Ti alpha transcript and no detectable surface Ti protein. Since previous studies demonstrated that Ti beta gene activation precedes Ti alpha gene activation in thymic ontogeny, the T11+T3- NK cells appear to be derived from T-lineage precursors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Receptores de Antígenos de Linfócitos T
/
Regulação da Expressão Gênica
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1985
Tipo de documento:
Article