Prostacyclin synthesis induced in vascular cells by interleukin-1.
Science
; 229(4709): 174-6, 1985 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-2409598
ABSTRACT
Supernatants from cultures of human monocytes that had been stimulated with endotoxin or silica induced the synthesis of prostacyclin in endothelial and smooth muscle cells. The lymphokine mediating these effects on the cells of the blood vessel wall was identified as interleukin-1; interferons and interleukin-2 were inactive. Interleukin-1-induced prostacyclin synthesis represents a new aspect of the interaction between the immune system (as well as other tissues) and the vessel wall and may serve as a basis for the development of new strategies in antithrombotic therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasos Sanguíneos
/
Epoprostenol
/
Interleucina-1
/
Endotélio
/
Músculo Liso
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1985
Tipo de documento:
Article