Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice.

Hanson, Miranda L; Hixon, Julie A; Li, Wenqing; Felber, Barbara K; Anver, Miriam R; Stewart, C Andrew; Janelsins, Brian M; Datta, Sandip K; Shen, Wei; McLean, Mairi H; Durum, Scott K

Hanson, Miranda L; Hixon, Julie A; Li, Wenqing; Felber, Barbara K; Anver, Miriam R; Stewart, C Andrew; Janelsins, Brian M; Datta, Sandip K; Shen, Wei; McLean, Mairi H; Durum, Scott K.

Afiliação

Hanson ML; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.
Hixon JA; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.
Li W; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.
Felber BK; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.
Anver MR; Laboratory Animal Services Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland.
Stewart CA; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.
Janelsins BM; Bacterial Pathogenesis Unit, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Datta SK; Bacterial Pathogenesis Unit, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Shen W; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.
McLean MH; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.
Durum SK; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland. Electronic address: durums@mail.nih.gov.

Gastroenterology ; 146(1): 210-221.e13, 2014 Jan.

Article em En | MEDLINE | ID: mdl-24120477

Assuntos

Sistemas de Liberação de Medicamentos/métodos; Enterocolite/imunologia; Fatores Imunológicos/administração & dosagem; Doenças Inflamatórias Intestinais; Interleucina-10/imunologia; Interleucinas/administração & dosagem; Mucosa Intestinal/imunologia; Lactococcus lactis; Administração Oral; Animais; Modelos Animais de Doenças; Fatores Imunológicos/farmacologia; Interleucinas/imunologia; Mucosa Intestinal/efeitos dos fármacos; Camundongos; Linfócitos T; Transformação Bacteriana

Palavras-chave

Crohn's Disease; DAI; DP; DSS; Ebi3; EpsteinBarr virusinduced protein 3; GI; IBD; IEL; IFN; IL; Immune Regulation; LAL; LL; LPS; Lactococcus lactis; MLN; Mouse Model; PBS; SI; T-helper cell; Th; Ulcerative Colitis; dextran sulfate sodium; disease activity index; double positive; gastrointestinal; inflammatory bowel disease; interferon; interleukin; intraepithelial lymphocyte; limulus amebocyte lysate; lipopolysaccharide; mRNA; mesenteric lymph node; messenger RNA; phosphate-buffered saline; recombinant mouse; rm; small intestine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Interleucinas / Interleucina-10 / Sistemas de Liberação de Medicamentos / Lactococcus lactis / Enterocolite / Fatores Imunológicos / Mucosa Intestinal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Gastroenterology Ano de publicação: 2014 Tipo de documento: Article

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