Firing rate homeostasis in visual cortex of freely behaving rodents.
Neuron
; 80(2): 335-42, 2013 Oct 16.
Article
em En
| MEDLINE
| ID: mdl-24139038
ABSTRACT
It has been postulated that homeostatic mechanisms maintain stable circuit function by keeping neuronal firing within a set point range, but such firing rate homeostasis has never been demonstrated in vivo. Here we use chronic multielectrode recordings to monitor firing rates in visual cortex of freely behaving rats during chronic monocular visual deprivation (MD). Firing rates in V1 were suppressed over the first 2 day of MD but then rebounded to baseline over the next 2-3 days despite continued MD. This drop and rebound in firing was accompanied by bidirectional changes in mEPSC amplitude measured ex vivo. The rebound in firing was independent of sleep-wake state but was cell type specific, as putative FS and regular spiking neurons responded to MD with different time courses. These data establish that homeostatic mechanisms within the intact CNS act to stabilize neuronal firing rates in the face of sustained sensory perturbations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Privação Sensorial
/
Córtex Visual
/
Potenciais de Ação
/
Homeostase
/
Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Revista:
Neuron
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos