Prevalence and clinical profiles of 'autoantibody-negative' systemic sclerosis subjects.
Clin Exp Rheumatol
; 32(6 Suppl 86): S-127-32, 2014.
Article
em En
| MEDLINE
| ID: mdl-24144389
ABSTRACT
OBJECTIVES:
To determine the prevalence of autoantibody negative systemic sclerosis (SSc) and to identify the clinical correlates thereof.METHODS:
Clinical data and sera from 874 SSc subjects were collected and autoantibodies were tested in a central laboratory using 1) indirect immunofluorescence (IIF), 2) commercially available ELISA, addressable laser bead immunoassay (ALBIA), and line immunoassay (LIA), and 3) a sensitive immunoprecipitation (IP) assay.RESULTS:
Fifteen (15; 1.7%) subjects were autoantibody negative by IIF, ELISA, ALBIA, LIA and IP, and 16 (1.8%) were antinuclear antibody (ANA) positive by IIF but otherwise negative by ELISA, ALBIA, LIA and IP. Thirty-seven (37; 4.2%) were ANA positive by IIF, autoantibody negative by commercially available immunoassays, but had autoantibodies identified by IP (including Th/To in 20). Autoantibody-negative subjects had generally less severe disease than positive subjects.CONCLUSIONS:
Autoantibody-negative SSc is rare (<2%) and appears to be associated with a favourable prognosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Anticorpos Antinucleares
/
Antígenos Nucleares
/
Esclerodermia Difusa
/
Esclerodermia Limitada
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Clin Exp Rheumatol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Canadá