Characterization of W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape.
Vaccine
; 31(50): 5934-9, 2013 Dec 05.
Article
em En
| MEDLINE
| ID: mdl-24144471
ABSTRACT
The purpose of this simple study was to characterize a panel of clinical isolates of Mycobacterium tuberculosis obtained from the Western Cape region of South Africa where new clinical vaccine trials are beginning, in the low dose aerosol guinea pig infection model. Most of the strains tested grew well in the lungs and other organs of these animals, and in most cases gave rise to moderate to very severe lung damage. We further observed that the current BCG vaccine was highly protective against two randomly selected strains, giving rise to significantly prolonged survival.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Mycobacterium tuberculosis
Limite:
Animals
/
Female
/
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2013
Tipo de documento:
Article