Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITG&#914;4-PDCD4) as predictor of metastatic tumor potential.

Ferraro, Angelo; Kontos, Christos K; Boni, Themis; Bantounas, Ioannis; Siakouli, Dimitra; Kosmidou, Vivian; Vlassi, Margarita; Spyridakis, Yannis; Tsipras, Iraklis; Zografos, George; Pintzas, Alexander

Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGΒ4-PDCD4) as predictor of metastatic tumor potential.

Ferraro, Angelo; Kontos, Christos K; Boni, Themis; Bantounas, Ioannis; Siakouli, Dimitra; Kosmidou, Vivian; Vlassi, Margarita; Spyridakis, Yannis; Tsipras, Iraklis; Zografos, George; Pintzas, Alexander.

Afiliação

Ferraro A; Laboratory of Signal Mediated Gene Expression; Institute of Biology, Medicinal Chemistry and Biotechnology; National Hellenic Research Foundation; Athens, Greece.
Kontos CK; Laboratory of Signal Mediated Gene Expression; Institute of Biology, Medicinal Chemistry and Biotechnology; National Hellenic Research Foundation; Athens, Greece.
Boni T; Laboratory of Signal Mediated Gene Expression; Institute of Biology, Medicinal Chemistry and Biotechnology; National Hellenic Research Foundation; Athens, Greece.
Bantounas I; Laboratory of Signal Mediated Gene Expression; Institute of Biology, Medicinal Chemistry and Biotechnology; National Hellenic Research Foundation; Athens, Greece.
Siakouli D; Laboratory of Signal Mediated Gene Expression; Institute of Biology, Medicinal Chemistry and Biotechnology; National Hellenic Research Foundation; Athens, Greece.
Kosmidou V; Laboratory of Signal Mediated Gene Expression; Institute of Biology, Medicinal Chemistry and Biotechnology; National Hellenic Research Foundation; Athens, Greece.
Vlassi M; Laboratory of Signal Mediated Gene Expression; Institute of Biology, Medicinal Chemistry and Biotechnology; National Hellenic Research Foundation; Athens, Greece.
Spyridakis Y; 3rd Department of Surgery; General Hospital of Athens G. Gennimatas; Athens, Greece.
Tsipras I; 3rd Department of Surgery; General Hospital of Athens G. Gennimatas; Athens, Greece.
Zografos G; 3rd Department of Surgery; General Hospital of Athens G. Gennimatas; Athens, Greece.
Pintzas A; Laboratory of Signal Mediated Gene Expression; Institute of Biology, Medicinal Chemistry and Biotechnology; National Hellenic Research Foundation; Athens, Greece.

Epigenetics ; 9(1): 129-41, 2014 Jan.

Article em En | MEDLINE | ID: mdl-24149370

Assuntos

Proteínas Reguladoras de Apoptose/metabolismo; Neoplasias Colorretais/genética; Epigênese Genética; Redes Reguladoras de Genes; Integrina beta4/genética; MicroRNAs/genética; Proteínas de Ligação a RNA/metabolismo; Biomarcadores Tumorais/metabolismo; Linhagem Celular Tumoral; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Transição Epitelial-Mesenquimal; Histonas/metabolismo; Humanos; Integrina beta4/metabolismo; MicroRNAs/metabolismo; Metástase Neoplásica; Processamento de Proteína Pós-Traducional; Proteína Proto-Oncogênica c-ets-1/metabolismo; Fator de Transcrição AP-1/metabolismo

Palavras-chave

ITGß4; RAS; epithelial-mesenchymal transition (EMT); histone modifications; metastasis markers; miR-21

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteínas de Ligação a RNA / Integrina beta4 / MicroRNAs / Epigênese Genética / Proteínas Reguladoras de Apoptose / Redes Reguladoras de Genes Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Epigenetics Assunto da revista: GENETICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Grécia

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