Prognosis of patients with systemic lupus erythematosus and discoid lesions.
An Bras Dermatol
; 88(5): 755-8, 2013.
Article
em En
| MEDLINE
| ID: mdl-24173181
ABSTRACT
BACKGROUND:
It has been observed that patients with systemic lupus erythematosus and discoid lesions have a milder systemic disease.OBJECTIVE:
To compare the clinical, demographic and autoantibody profile of systemic lupus erythematosus patients with and without discoid lesions.METHODS:
We carried out a retrospective study involving 288 systemic lupus erythematosus patients who met at least four classification criteria of the American College of Rheumatology for systemic lupus erythematosus, comparing the clinical, serological and demographic factors between patients with and without discoid manifestations.RESULTS:
Of the 288 patients, 13.8% had discoid lesions. Univariate analysis found no differences in the prevalence of malar rash, photosensitivity, arthritis, serositis, leukopenia, lymphopenia and hemolytic anemia or anemia of the central nervous system (p = ns). Renal lesions were more common in those without discoid lesions (p =0.016), and hemolysis (p<0.0001) was more common in those with discoid lesions. Regarding the profile of autoantibodies, only the anti-RNP antibody was more common in those with discoid events (p =0.04). In a logistic regression study, only the renal lesions and anti-RNP maintained their associations with discoid manifestations.CONCLUSION:
Patients with lesions of systemic lupus erythematosus and discoid lesions have lower prevalence of renal involvement and a greater presence of anti RNP.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lúpus Eritematoso Discoide
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
An Bras Dermatol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Brasil