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Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus.
Germi, R; Mariette, C; Alain, S; Lupo, J; Thiebaut, A; Brion, J P; Epaulard, O; Saint Raymond, C; Malvezzi, P; Morand, P.
Afiliação
  • Germi R; Department of Virology, University Hospital, Grenoble, France; Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, B.P. 181, 6, rue Jules Horowitz, 38042 Grenoble Cedex 9, France. Electronic address: rgermi@chu-grenoble.fr.
  • Mariette C; Department of Infectious diseases, University Hospital, Grenoble, France.
  • Alain S; Department of Virology, French National Cytomegalovirus Reference Center, University Hospital, Limoges, France.
  • Lupo J; Department of Virology, University Hospital, Grenoble, France; Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, B.P. 181, 6, rue Jules Horowitz, 38042 Grenoble Cedex 9, France.
  • Thiebaut A; Department of Hematology, University Hospital, Grenoble, France.
  • Brion JP; Department of Infectious diseases, University Hospital, Grenoble, France.
  • Epaulard O; Department of Virology, University Hospital, Grenoble, France; Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, B.P. 181, 6, rue Jules Horowitz, 38042 Grenoble Cedex 9, France; Department of Infectious diseases, University Hospital, Grenoble, France.
  • Saint Raymond C; Department of Pneumology, University Hospital, Grenoble, France.
  • Malvezzi P; Department of Nephrology, University Hospital, Grenoble, France.
  • Morand P; Department of Virology, University Hospital, Grenoble, France; Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, B.P. 181, 6, rue Jules Horowitz, 38042 Grenoble Cedex 9, France.
Antiviral Res ; 101: 57-61, 2014 Jan.
Article em En | MEDLINE | ID: mdl-24184983
ABSTRACT
Cytomegalovirus (CMV) strains resistant to ganciclovir, cidofovir and/or foscarnet were genotypically and phenotypically characterised in two haematopoietic stem cell transplant recipients and three solid-organ transplant recipients with CMV disease. The anti-malaria drug artesunate led to a favourable virological and clinical response in three cases with mild CMV diseases (fever and neutropaenia) but was ineffective in two fatal CMV diseases with lung involvement in spite of a decrease in the CMV DNA load in blood and bronchoalveolar fluid.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Infecções por Citomegalovirus / Citomegalovirus / Farmacorresistência Viral / Artemisininas Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Antiviral Res Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Infecções por Citomegalovirus / Citomegalovirus / Farmacorresistência Viral / Artemisininas Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Antiviral Res Ano de publicação: 2014 Tipo de documento: Article