Fractionated Ocimum gratissimum leaf extract inhibit prostate cancer (PC3·AR) cells growth by reducing androgen receptor and survivin levels.
J Health Care Poor Underserved
; 24(4 Suppl): 61-9, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24241261
ABSTRACT
In this study, the antiproliferative activity of the organic solvent-soluble and aqueous extracts of Ocimum gratissimum leaf against the prostate cancer cells PC3·AR were evaluated by their inhibitory effects on the Androgen Receptor (AR) and Survivin protein. Two organic solvent-soluble extracts P2 and P3-2, and a water- soluble extract, PS/PT1, were found to reduce AR and Survivin levels in a time-dependent manner. In addition, extract PS/PT1, also exhibited the inhibitory activity in a dose-dependent manner. This is the first time that the inhibitory eff ects of O. gratissimum extracts have been evaluated on the Androgen Receptor (AR) and Survivin protein. The results encouraged the further studies of O. gratissimum as a potential treatment of prostate cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Extratos Vegetais
/
Receptores Androgênicos
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Ocimum
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Proliferação de Células
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Proteínas Inibidoras de Apoptose
Limite:
Humans
/
Male
Idioma:
En
Revista:
J Health Care Poor Underserved
Assunto da revista:
SERVICOS DE SAUDE
Ano de publicação:
2013
Tipo de documento:
Article