Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A
; 110(49): E4790-7, 2013 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-24248369
ABSTRACT
Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Modelos Moleculares
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Vesículas Transportadoras
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Imunomodulação
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Lipoproteínas
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Proteínas de Membrana
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Mycobacterium tuberculosis
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2013
Tipo de documento:
Article