The uncertain significance of low vitamin D levels in African descent populations: a review of the bone and cardiometabolic literature.
Prog Cardiovasc Dis
; 56(3): 261-9, 2013.
Article
em En
| MEDLINE
| ID: mdl-24267433
ABSTRACT
Vitamin D levels in people of African descent are often described as inadequate or deficient. Whether low vitamin D levels in people of African descent lead to compromised bone or cardiometabolic health is unknown. Clarity on this issue is essential because if clinically significant vitamin D deficiency is present, vitamin D supplementation is necessary. However, if vitamin D is metabolically sufficient, vitamin D supplementation could be wasteful of scarce resources and even harmful. In this review vitamin D physiology is described with a focus on issues specific to populations of African descent such as the influence of melanin on endogenous vitamin D production and lactose intolerance on the willingness of people to ingest vitamin D fortified foods. Then data on the relationship of vitamin D to bone and cardiometabolic health in people of African descent are evaluated.
Palavras-chave
African Diaspora; African-Americans; Africans; BMD; FDA; Federal Drug Administration; IOM; Institute of Medicine; Lactose Intolerance; Melanin; NHANES; National Health and Nutrition Examination Survey; PTH; UVB; VDR; Vitamin D; WHI-OS; Women's Health InitiativeObservational Study; bone mineral density; parathyroid hormone; ultraviolet B; vitamin D receptor
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoporose
/
Vitamina D
/
Deficiência de Vitamina D
/
Doenças Cardiovasculares
/
População Negra
Tipo de estudo:
Etiology_studies
Limite:
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
Prog Cardiovasc Dis
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Moldávia