Idiopathic premature ovarian failure: what is the most suitable ovarian stimulation protocol?
Clin Exp Obstet Gynecol
; 40(3): 327-30, 2013.
Article
em En
| MEDLINE
| ID: mdl-24283158
ABSTRACT
OBJECTIVE:
To evaluate the ovarian response to ovarian stimulation in women with idiopathic premature ovarian failure (POF) in a prospective, controlled, and sequential crossover pilot study. MATERIALS ANDMETHODS:
Ten women with idiopathic premature ovarian failure and normal karyotype were included in the study. Phase I was comprised of three consecutive control cycles consisting each of estrogen progestin sequential therapy. Phase II was comprised of three consecutive treatment cycles combining the use of gonadotropin-releasing hormone agonist (GnRHa) in the background of estrogen priming, followed by gonadotropin ovarian stimulation and corticosteroid immunosuppression.RESULTS:
Ovulation rates in the treatment cycles (0/10; 0%) did not differ from control cycles (0/10; 0%).CONCLUSIONS:
The findings of this pilot study showed that the combination of estrogen priming, corticosteroid immune-suppression, GnRHa pituitary desensitization, and followed by gonadotropin ovarian stimulation is ineffective in restoring ovarian function in women with idiopathic POF.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Indução da Ovulação
/
Insuficiência Ovariana Primária
Tipo de estudo:
Guideline
Limite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Clin Exp Obstet Gynecol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Líbano