Synthesis of stable isotope labeled anacetrapib, its major metabolites and [(14) C]anacetrapib.
J Labelled Comp Radiopharm
; 56(12): 600-8, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-24285236
ABSTRACT
Cholesteryl ester transfer protein inhibitors are an important class of compounds designed to treat hypocholesterolemia and prevent cardiovascular disease. Anacetrapib (MK-0859) is currently in phase III trials for the treatment of elevated cholesterol levels and prevention of cardiovascular disease. In order to further support the development of anacetrapib, we prepared [M + 6]MK-0859, which was required in support of an absolute bioavailability study of the active pharmaceutical ingredient (API). Additional support included the synthesis of an internal standard [M + 13] and three stable isotope labeled metabolites, which were used to analyze clinical samples, and [(14) C]MK-0859 to support drug metabolism studies.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Radiofarmacêuticos
/
Oxazolidinonas
/
Anticolesterolemiantes
Idioma:
En
Revista:
J Labelled Comp Radiopharm
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos