Pharmacokinetics and treatment efficacy of camptothecin nanocrystals on lung metastasis.
Mol Pharm
; 11(1): 226-33, 2014 Jan 06.
Article
em En
| MEDLINE
| ID: mdl-24294887
ABSTRACT
Cancer metastasis is difficult to treat, and its outcome becomes dreadful for a patient. Lung is a major metastatic site for many types of cancers, and the need for finding effective treatment for lung metastasis cannot be overemphasized. In a previous study, we showed that camptothecin nanocrystals demonstrated greater anticancer efficacy and achieved significantly higher concentration in lungs than a conventional, solution-based formulation. In this study, we further determined the pharmacokinetics of camptothecin nanocrystals in rats and investigated treatment efficacy in mice against metastatic lung tumors. The results show that camptothecin nanocrystals were capable of eliciting greater antimetastatic efficacy and achieve a longer survival time in the murine model compared with camptothecin salt solution. The study suggests that using engineered, solid nanoparticles may be a feasible approach in the treatment of lung cancer and lung metastatic cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Camptotecina
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Nanopartículas
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Neoplasias Pulmonares
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Mol Pharm
Assunto da revista:
BIOLOGIA MOLECULAR
/
FARMACIA
/
FARMACOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China