Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells.

Zhu, Saiyong; Ambasudhan, Rajesh; Sun, Woong; Kim, Hyun Jung; Talantova, Maria; Wang, Xiaojing; Zhang, Mingliang; Zhang, Yu; Laurent, Timothy; Parker, James; Kim, Han-Seop; Zaremba, Jeffrey D; Saleem, Sofiyan; Sanz-Blasco, Sara; Masliah, Eliezer; McKercher, Scott R; Cho, Yee Sook; Lipton, Stuart A; Kim, Janghwan; Ding, Sheng

Zhu, Saiyong; Ambasudhan, Rajesh; Sun, Woong; Kim, Hyun Jung; Talantova, Maria; Wang, Xiaojing; Zhang, Mingliang; Zhang, Yu; Laurent, Timothy; Parker, James; Kim, Han-Seop; Zaremba, Jeffrey D; Saleem, Sofiyan; Sanz-Blasco, Sara; Masliah, Eliezer; McKercher, Scott R; Cho, Yee Sook; Lipton, Stuart A; Kim, Janghwan; Ding, Sheng.

Afiliação

Zhu S; Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Ambasudhan R; Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Sun W; Department of Anatomy, Korea University College of Medicine, Seoul 136-705, Korea.
Kim HJ; Department of Anatomy, Korea University College of Medicine, Seoul 136-705, Korea.
Talantova M; Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Wang X; Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Zhang M; Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Zhang Y; Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Laurent T; Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Parker J; Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Kim HS; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Korea.
Zaremba JD; Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Saleem S; Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Sanz-Blasco S; Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Masliah E; Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
McKercher SR; Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cho YS; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Korea.
Lipton SA; 1] Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA [2] Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Kim J; 1] Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA [2] Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daeje
Ding S; Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.

Cell Res ; 24(1): 126-9, 2014 Jan.

Article em En | MEDLINE | ID: mdl-24296783

Assuntos

Reprogramação Celular/genética; Células-Tronco Pluripotentes Induzidas/citologia; Células-Tronco Neurais/citologia; Fator 3 de Transcrição de Octâmero/genética; Fatores de Transcrição SOXB1/genética; 2-Amino-5-fosfonovalerato/farmacologia; Animais; Células Cultivadas; Proteínas do Olho/biossíntese; Proteínas do Olho/genética; Fibroblastos; Expressão Gênica/genética; Regulação da Expressão Gênica no Desenvolvimento/genética; Proteínas de Fluorescência Verde/genética; Histonas/genética; Proteínas de Homeodomínio/biossíntese; Proteínas de Homeodomínio/genética; Humanos; Camundongos; Dados de Sequência Molecular; Fator 3 de Transcrição de Octâmero/biossíntese; Fator de Transcrição PAX6; Fatores de Transcrição Box Pareados/biossíntese; Fatores de Transcrição Box Pareados/genética; Regiões Promotoras Genéticas; Receptores de N-Metil-D-Aspartato/antagonistas & inibidores; Receptores de N-Metil-D-Aspartato/genética; Proteínas Repressoras/biossíntese; Proteínas Repressoras/genética; Fatores de Transcrição SOXB1/biossíntese

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator 3 de Transcrição de Octâmero / Reprogramação Celular / Fatores de Transcrição SOXB1 / Células-Tronco Pluripotentes Induzidas / Células-Tronco Neurais Limite: Animals / Humans Idioma: En Revista: Cell Res Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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