Targeting the splicing of mRNA in autoimmune diseases: BAFF inhibition in Sjögren's syndrome as a proof of concept.

Roescher, N; Vosters, J L; Alsaleh, G; Dreyfus, P; Jacques, S; Chiocchia, G; Sibilia, J; Tak, P P; Chiorini, J A; Mariette, X; Gottenberg, Jacques-Eric

Roescher, N; Vosters, J L; Alsaleh, G; Dreyfus, P; Jacques, S; Chiocchia, G; Sibilia, J; Tak, P P; Chiorini, J A; Mariette, X; Gottenberg, Jacques-Eric.

Afiliação

Roescher N; 1] Division of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands [2] Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Vosters JL; 1] Division of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands [2] Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Alsaleh G; ImmunoRhumatologie Moléculaire, INSERM UMR_S 1109, Faculté de Médecine Université de Strasbourg; Centre de Recherche d'Immunologie et d'Hématologie, Fédération de Médecine Translationnelle de Strasbourg, Service de Rhumatologie, Hôpital Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg,
Dreyfus P; UPMC Um76, Inserm U974, CNRS UMR7215, Institut de Myologie, 105 Bd de l'Hôpital, Paris, France.
Jacques S; Inserm, U1016; Institut Cochin, CNRS, UMR8104, Université Paris Descartes, Paris, France.
Chiocchia G; Inserm, U1016; Institut Cochin, CNRS, UMR8104, Université Paris Descartes, Paris, France.
Sibilia J; ImmunoRhumatologie Moléculaire, INSERM UMR_S 1109, Faculté de Médecine Université de Strasbourg; Centre de Recherche d'Immunologie et d'Hématologie, Fédération de Médecine Translationnelle de Strasbourg, Service de Rhumatologie, Hôpital Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg,
Tak PP; Division of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands.
Chiorini JA; Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Mariette X; Université Paris-Sud; INSERM U1012; AP-HP, Hôpitaux universitaires Paris-Sud; Le Kremlin Bicêtre, France.
Gottenberg JE; ImmunoRhumatologie Moléculaire, INSERM UMR_S 1109, Faculté de Médecine Université de Strasbourg; Centre de Recherche d'Immunologie et d'Hématologie, Fédération de Médecine Translationnelle de Strasbourg, Service de Rhumatologie, Hôpital Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg,

Mol Ther ; 22(4): 821-7, 2014 Apr.

Article em En | MEDLINE | ID: mdl-24304965

Assuntos

Fator Ativador de Células B/biossíntese; RNA Mensageiro/genética; Síndrome de Sjogren/genética; Síndrome de Sjogren/terapia; Animais; Fator Ativador de Células B/antagonistas & inibidores; Fator Ativador de Células B/genética; Linfócitos B/metabolismo; Linfócitos B/patologia; Dependovirus; Éxons/genética; Humanos; Ativação Linfocitária/genética; Camundongos; Camundongos Endogâmicos NOD/genética; Camundongos Endogâmicos NOD/metabolismo; Splicing de RNA/genética; RNA Mensageiro/antagonistas & inibidores; RNA Nuclear Pequeno/genética; Síndrome de Sjogren/patologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Síndrome de Sjogren / Fator Ativador de Células B Limite: Animals / Humans Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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