Complementary strategies for developing Gd-free high-field T1 MRI contrast agents based on Mn(III) porphyrins.
J Med Chem
; 57(2): 516-20, 2014 Jan 23.
Article
em En
| MEDLINE
| ID: mdl-24328058
ABSTRACT
Mn(III) porphyrin (MnP) holds the promise of addressing the emerging challenges associated with Gd-based clinical MRI contrast agents (CAs), namely, Gd-related adverse effect and decreasing sensitivity at high clinical magnetic fields. Two complementary strategies for developing new MnPs as Gd-free CAs with optimized biocompatibility were established to improve relaxivity or clearance rate. MnPs with distinct and tunable pharmacokinetic properties can consequently be constructed for different in vivo applications at clinical field of 3 T.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Porfirinas
/
Compostos de Bifenilo
/
Meios de Contraste
/
Complexos de Coordenação
/
Manganês
/
Metaloporfirinas
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Canadá