Practical and cost-effective manufacturing route for the synthesis of a ß-lactamase inhibitor.
Org Lett
; 16(1): 174-7, 2014 Jan 03.
Article
em En
| MEDLINE
| ID: mdl-24329136
ABSTRACT
Compound 1, a potent and irreversible inhibitor of ß-lactamases, is in clinical trials with ß-lactam antibiotics for the treatment of serious and antibiotic-resistant bacterial infections. A short, scalable, and cost-effective route for the production of this densely functionalized polycyclic molecule is described.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Policíclicos
/
Inibidores Enzimáticos
/
Compostos Azabicíclicos
/
Inibidores de beta-Lactamases
/
Antibacterianos
Tipo de estudo:
Health_economic_evaluation
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos