Counting platelets at transfusion threshold levels: impact on the decision to transfuse. A BEST Collaborative - UK NEQAS(H) International Exercise.
Vox Sang
; 106(4): 330-6, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24330101
ABSTRACT
BACKGROUND AND OBJECTIVES:
Obtaining accurate and precise platelet enumeration in automatic platelet analysers at low platelet counts is a challenge. To explore the performance of current haematology analysers in counting platelet concentrations usually used as platelet transfusion threshold. MATERIAL ANDMETHODS:
An international exercise where four blood samples with platelet levels near usual platelet transfusion thresholds was prepared and distributed.RESULTS:
The samples shipped had a platelet count of 6·3, 13·3, 21·6 and 53·0 × 10(9) /l according to the international reference method. We received 82 sets of results from nine countries. Instruments from six different manufacturers were represented. Although the mean count for each of the four samples was very similar to the values, according to the reference method (9·0, 16·2, 23·0 and 57·6 × 10(9) /l), significant variability in the results was found. Assuming that these were patient samples and the result of the count used to indicate a prophylactic platelet transfusion, undertransfusion would have occurred for 24·5% of the LP1 samples at a transfusion threshold of 10 × 10(9) /l and, at a threshold of 20 × 10(9) /l, undertransfusion would have occurred for 7·2% of the LP1 and 16·2% of the LP2 samples and overtransfusion would have occurred with 23·1% of the LP3 samples.CONCLUSION:
The results suggest that significant inaccuracy exists in counting low levels of platelets and that this inaccuracy might have a significant impact in under- and overtransfusion of platelet concentrates to patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transfusão de Plaquetas
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Aged
/
Humans
Idioma:
En
Revista:
Vox Sang
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Espanha