Ribavirin antagonizes the effect of azidothymidine on HIV replication.
Science
; 235(4794): 1376-9, 1987 Mar 13.
Article
em En
| MEDLINE
| ID: mdl-2435003
ABSTRACT
Azidothymidine and ribavirin both inhibit replication of human immunodeficiency virus in vitro and show promise of clinical utility in patients infected with this virus. In this study, the possible interactions of these drugs were examined in vitro, and a reproducible antagonism between azidothymidine and ribavirin was found to occur under a variety of experimental conditions. The mechanism responsible for this antagonism appeared to be inhibition of azidothymidine phosphorylation by ribavirin. Because similar effects may occur in vivo, clinical trials of these two drugs in combination must be performed only under carefully controlled conditions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribavirina
/
Ribonucleosídeos
/
Timidina
/
HIV
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1987
Tipo de documento:
Article