Insights into the molecular basis of action of the AT1 antagonist losartan using a combined NMR spectroscopy and computational approach.

Zervou, Maria; Cournia, Zoe; Potamitis, Constantinos; Patargias, George; Durdagi, Serdar; Grdadolnik, Simona Golic; Mavromoustakos, Thomas

Zervou, Maria; Cournia, Zoe; Potamitis, Constantinos; Patargias, George; Durdagi, Serdar; Grdadolnik, Simona Golic; Mavromoustakos, Thomas.

Afiliação

Zervou M; National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry & Biotechnology, Vas. Constantinou 48, 11635 Athens, Greece. Electronic address: mzervou@eie.gr.
Cournia Z; Biomedical Research Foundation of the Academy of Athens, 4, Soranou Efesiou, 11527 Athens, Greece.
Potamitis C; National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry & Biotechnology, Vas. Constantinou 48, 11635 Athens, Greece.
Patargias G; Biomedical Research Foundation of the Academy of Athens, 4, Soranou Efesiou, 11527 Athens, Greece.
Durdagi S; National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry & Biotechnology, Vas. Constantinou 48, 11635 Athens, Greece.
Grdadolnik SG; Laboratory of Biomolecular Structure, National Institute of Chemistry, Hajdrihova 19, POB 30, SI-1115 Ljubljana, Slovenia; EN-FIST Centre of Excellence, Dunajska 156, SI-1000 Ljubljana, Slovenia.
Mavromoustakos T; National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry & Biotechnology, Vas. Constantinou 48, 11635 Athens, Greece; Chemistry Department of National Capodistrian University, Zographou, Athens 15784, Greece.

Biochim Biophys Acta ; 1838(3): 1031-46, 2014 Mar.

Article em En | MEDLINE | ID: mdl-24374319

Assuntos

Membrana Celular/metabolismo; Biologia Computacional; Bicamadas Lipídicas/metabolismo; Losartan/farmacologia; Espectroscopia de Ressonância Magnética; Receptor Tipo 1 de Angiotensina/química; Varredura Diferencial de Calorimetria; Domínio Catalítico; Humanos; Micelas; Modelos Moleculares; Simulação de Dinâmica Molecular; Conformação Proteica; Receptores Acoplados a Proteínas G/metabolismo; Marcadores de Spin

Palavras-chave

Losartan; Molecular dynamics in micelles; Molecular dynamics in phospholipid bilayers with embedded AT(1) receptor; NMR (DOSY, NOESY/ROESY); SDS micelles; Spin labels

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectroscopia de Ressonância Magnética / Membrana Celular / Biologia Computacional / Losartan / Receptor Tipo 1 de Angiotensina / Bicamadas Lipídicas Limite: Humans Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2014 Tipo de documento: Article

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