Orotate uptake and metabolism in normal and neoplastic tissues.
Comp Biochem Physiol B
; 86(3): 581-6, 1987.
Article
em En
| MEDLINE
| ID: mdl-2439254
ABSTRACT
The uptake of [3H]orotate was greater in mouse liver than in hepatoma but the difference was less marked than in the rat. Of the tissues examined, a high uptake of [3H]orotate was restricted to the liver and kidney in rat, mouse and guinea-pig. We confirmed that a high orotate diet greatly increases the ratio of UTP to ATP concentration in rat liver but we observed that there is little change of this nucleotide ratio in kidney. Evidence was obtained for a different pattern of orotate metabolism in rat liver and kidney.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Orótico
/
Melanoma Experimental
/
RNA
/
Rim
/
Fígado
/
Neoplasias Hepáticas Experimentais
Limite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol B
Ano de publicação:
1987
Tipo de documento:
Article