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The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.
Wilkinson, Craig; McPhillie, Martin J; Zhou, Ying; Woods, Stuart; Afanador, Gustavo A; Rawson, Shaun; Khaliq, Farzana; Prigge, Sean T; Roberts, Craig W; Rice, David W; McLeod, Rima; Fishwick, Colin W; Muench, Stephen P.
Afiliação
  • Wilkinson C; School of Biomedical Sciences, University of Leeds, Leeds, UK.
  • McPhillie MJ; Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, UK.
  • Zhou Y; Department of Ophthalmology and Visual Sciences, Pediatrics (Infectious Diseases), Committees on Genetics, Immunology, and Molecular Medicine, Institute of Genomics and Systems Biology, and The College, The University of Chicago, Chicago, IL 60637, United States.
  • Woods S; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
  • Afanador GA; Johns Hopkins School of Public Health, Rm. E5132, 615 N. Wolfe St., Baltimore, MD 21205, United States.
  • Rawson S; School of Biomedical Sciences, University of Leeds, Leeds, UK.
  • Khaliq F; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
  • Prigge ST; Johns Hopkins School of Public Health, Rm. E5132, 615 N. Wolfe St., Baltimore, MD 21205, United States.
  • Roberts CW; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
  • Rice DW; Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, UK.
  • McLeod R; Department of Ophthalmology and Visual Sciences, Pediatrics (Infectious Diseases), Committees on Genetics, Immunology, and Molecular Medicine, Institute of Genomics and Systems Biology, and The College, The University of Chicago, Chicago, IL 60637, United States.
  • Fishwick CW; School of Chemistry, University of Leeds, Leeds, UK.
  • Muench SP; School of Biomedical Sciences, University of Leeds, Leeds, UK. Electronic address: s.p.muench@leeds.ac.uk.
Bioorg Med Chem Lett ; 24(3): 911-6, 2014 Feb 01.
Article em En | MEDLINE | ID: mdl-24398298
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxoplasma / Benzimidazóis / Sistemas de Liberação de Medicamentos / Enoil-(Proteína de Transporte de Acila) Redutase (NADH) Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxoplasma / Benzimidazóis / Sistemas de Liberação de Medicamentos / Enoil-(Proteína de Transporte de Acila) Redutase (NADH) Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido