[Effects of melaxen and valdoxan on the activity of glutathione antioxidant system and NADPH-producing enzymes in rat heart under experimental hyperthyroidism conditions].
Eksp Klin Farmakol
; 76(10): 12-5, 2013.
Article
em Ru
| MEDLINE
| ID: mdl-24400382
ABSTRACT
The effects of melaxen and valdoxan on the activity of glutathione antioxidant system and some NADPH-producing enzymes have been studied under conditions of experimental hyperthyroidism in rat heart. Under the action of these drugs, reduced glutathione (GSH) content increased as compared to values observed under the conditions of pathology. It has been established that the activities of glutathione reductase (GR), glutathione peroxidase (GP), glucose-6-phosphate dehydrogenase, and NADP isocitrate dehydrogenase (increased under pathological conditions) change toward the intact control values upon the introduction of both drugs. The influence of melaxen and valdoxan, capable of producing antioxidant effect, leads apparently to the inhibition of free-radical oxidation processes and, as a consequence, the reduction of mobilization degree of the glutathione antioxidant system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glutationa
/
Coração
/
Hipertireoidismo
/
Acetamidas
/
Melatonina
/
NADP
/
Antioxidantes
Limite:
Animals
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article