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[Analgesic effect of CQM on prosopalgia model rats and its impact on exciting amino acid neurotransmitters].
Wang, Ye; Wang, Dan-Qiao; Cui, Yue; Zhang, Ying; Sun, Dan-Dan; Zhao, Xiao-Liang; Liu, Yang; Zhang, Mei-Yu; Jiao, Yue; Xu, Xiao-Jun; Xu, Shi.
Afiliação
  • Wang Y; Medical Experimental Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China. wyamber@hotmail.com
  • Wang DQ; Medical Experimental Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
  • Cui Y; Norman Bethune Medical School, Jilin University, Changchun 130000, China.
  • Zhang Y; Medical Experimental Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
  • Sun DD; Medical Experimental Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
  • Zhao XL; Medical Experimental Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
  • Liu Y; Medical Experimental Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
  • Zhang MY; Medical Experimental Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
  • Jiao Y; Medical Experimental Center, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
  • Xu XJ; Karolinska University Hospital, Stockholm 141 86, Sweden.
  • Xu S; Life Sciences Institute, Capital Normal University, Beijing 100048, China.
Zhongguo Zhong Yao Za Zhi ; 38(20): 3554-9, 2013 Oct.
Article em Zh | MEDLINE | ID: mdl-24490572
OBJECTIVE: To observe the analgesic effect of CQM on photochemically-induced prosopalgia model rats, and discuss its impact on the exciting amino acid neurotransmitter-glutamate (Glu). METHOD: Male SD rats were randomly divided into the sham operation group and the prosopalgia group. And the latter was subdivided into the model group, the gabapentin group (100 mg kg(-1)), and the CQM low-dose (35 mg x kg(-1)) and CQM high-dose (70 mg x kg(-1)) groups. The mechanical allodynia test was adopted to evaluate the pain behavior of rats, and reflect the efficacy with the mechanical withdrawal thresholds. The rat striatum extra-cellular fluid was collected by brain micro-dialysis. The Glu level of samples was measured by high performance liquid chromatography-fluorescene detector (HPLC-FLD). RESULT: Compared to the control group, the threshold of the mechanical allodynia of the IoN injury group was decreased significantly (P < 0.05), and the concentration of Glu was increased dramatically (P < 0.05). Compared to the model group, the mechanical allodynia of photochemically-induced prosopalgia model rats increased significantly (P < 0.01), with a notable increase in brain Glu concentration (P < 0.05). Compared with the model group, all of mechanical withdrawal thresholds increased. Among them, the CQM high-dose group showed a remarkably growth at three time points (P < 0.05), with the maximum up to (23 +/- 7.3) g. And the gabapentin group showed a remarkably growth at two time points (P < 0.05), with the maximum up to (20.5 +/- 9.2) g. All of the drug groups showed significantly lower Glu concentrations in rat brains than the model group (P < 0.05). CONCLUSION: CQM can ease the mechanical allodynia of photochemically-induced prosopalgia model rats. Its analgesic effect may be related to the decrease of Glu concentrations in striatum extra-cellular fluid.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Medicamentos de Ervas Chinesas / Neurotransmissores / Ácido Glutâmico / Doenças do Nervo Trigêmeo Limite: Animals / Humans / Male Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Assunto da revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Medicamentos de Ervas Chinesas / Neurotransmissores / Ácido Glutâmico / Doenças do Nervo Trigêmeo Limite: Animals / Humans / Male Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Assunto da revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China