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Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.
Kulminski, Alexander M; Arbeev, Konstantin G; Culminskaya, Irina; Arbeeva, Liubov; Ukraintseva, Svetlana V; Stallard, Eric; Christensen, Kaare; Schupf, Nicole; Province, Michael A; Yashin, Anatoli I.
Afiliação
  • Kulminski AM; Center for Population Health and Aging, Duke University, Durham, North Carolina, United States of America ; Institute for Genome Science and Policy, Duke University, Durham, North Carolina, United States of America ; Social Science Research Institute, Duke University, Durham, North Carolina, United
  • Arbeev KG; Center for Population Health and Aging, Duke University, Durham, North Carolina, United States of America ; Social Science Research Institute, Duke University, Durham, North Carolina, United States of America.
  • Culminskaya I; Center for Population Health and Aging, Duke University, Durham, North Carolina, United States of America ; Social Science Research Institute, Duke University, Durham, North Carolina, United States of America.
  • Arbeeva L; Center for Population Health and Aging, Duke University, Durham, North Carolina, United States of America.
  • Ukraintseva SV; Center for Population Health and Aging, Duke University, Durham, North Carolina, United States of America ; Institute for Genome Science and Policy, Duke University, Durham, North Carolina, United States of America ; Social Science Research Institute, Duke University, Durham, North Carolina, United
  • Stallard E; Center for Population Health and Aging, Duke University, Durham, North Carolina, United States of America ; Social Science Research Institute, Duke University, Durham, North Carolina, United States of America.
  • Christensen K; The Danish Aging Research Center, University of Southern Denmark, Odense, Denmark ; Department of Clinical Genetics and Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
  • Schupf N; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.
  • Province MA; Washington University School of Medicine, Division of Statistical Genomics, St. Louis, Missouri, United States of America.
  • Yashin AI; Center for Population Health and Aging, Duke University, Durham, North Carolina, United States of America ; Institute for Genome Science and Policy, Duke University, Durham, North Carolina, United States of America ; Social Science Research Institute, Duke University, Durham, North Carolina, United
PLoS Genet ; 10(1): e1004141, 2014 Jan.
Article em En | MEDLINE | ID: mdl-24497847
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores Etários / Caracteres Sexuais / Apolipoproteína E4 / Longevidade / Neoplasias Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores Etários / Caracteres Sexuais / Apolipoproteína E4 / Longevidade / Neoplasias Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2014 Tipo de documento: Article