[Impact of continuous blood purification on T cell subsets in children with severe sepsis].
Zhongguo Dang Dai Er Ke Za Zhi
; 16(2): 194-7, 2014 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-24568917
ABSTRACT
OBJECTIVE:
To investigate the impact of continuous blood purification (CBP) on T-cell subsets and prognosis in children with severe sepsis.METHODS:
A total of 42 children with severe sepsis were randomly divided into a control group (n=22) and a CBP group (n=20). The patients in the control group received conventional treatment, while those in the CBP group underwent continuous veno-venous hemofiltration daily 12-24 hours for 3 days besides conventional treatment. Changes in clinical variables and in peripheral blood regulatory T cell subsets were assessed 3 and 7 days after treatment.RESULTS:
The pediatric intensive care unit length of stay and duration of mechanical ventilation were significantly shortened and the 28-day mortality rate was significantly lower in the CPB treatment group as compared with the control group (P<0.05). In the CBP treatment group, the percentage of CD3(+), CD4(+), CD8(+) T cell populations and PCIS scores were significantly higher at 3 and 7 days after treatment than before treatment (P<0.05). At 7 days after treatment, the percentage of CD3(+), CD4(+), CD8(+) T cell populations, CD4(+)/CD8(+) ratio and PCIS scores were significantly higher in the CBP group than in the control group (P<0.05).CONCLUSIONS:
The CBP treatment may counteract the suppression of immune function and thus improve prognosis in children with severe sepsis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos T
/
Hemofiltração
/
Sepse
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China