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LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma.
Lossos, Chen; Bayraktar, Soley; Weinzierl, Elizabeth; Younes, Sheren F; Hosein, Peter J; Tibshirani, Robert J; Sutton Posthumus, Jocelyn; DeAngelis, Lisa M; Raizer, Jeffrey; Schiff, David; Abrey, Lauren; Natkunam, Yasodha; Lossos, Izidore S.
Afiliação
  • Lossos C; Division of Hematology-Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Br J Haematol ; 165(5): 640-8, 2014 Jun.
Article em En | MEDLINE | ID: mdl-24571259
Primary central nervous system lymphoma (PCNSL) is an aggressive sub-variant of non-Hodgkin lymphoma (NHL) with morphological similarities to diffuse large B-cell lymphoma (DLBCL). While methotrexate (MTX)-based therapies have improved patient survival, the disease remains incurable in most cases and its pathogenesis is poorly understood. We evaluated 69 cases of PCNSL for the expression of HGAL (also known as GCSAM), LMO2 and BCL6 - genes associated with DLBCL prognosis and pathobiology, and analysed their correlation to survival in 49 PCNSL patients receiving MTX-based therapy. We demonstrate that PCNSL expresses LMO2, HGAL(also known as GCSAM) and BCL6 proteins in 52%, 65% and 56% of tumours, respectively. BCL6 protein expression was associated with longer progression-free survival (P = 0·006) and overall survival (OS, P = 0·05), while expression of LMO2 protein was associated with longer OS (P = 0·027). Further research is needed to elucidate the function of BCL6 and LMO2 in PCNSL.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / Biomarcadores Tumorais / Proteínas Proto-Oncogênicas / Neoplasias do Sistema Nervoso Central / Proteínas Adaptadoras de Transdução de Sinal / Proteínas de Ligação a DNA / Proteínas com Domínio LIM Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Br J Haematol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / Biomarcadores Tumorais / Proteínas Proto-Oncogênicas / Neoplasias do Sistema Nervoso Central / Proteínas Adaptadoras de Transdução de Sinal / Proteínas de Ligação a DNA / Proteínas com Domínio LIM Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Br J Haematol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos