Angiogenic factors and uterine Doppler velocimetry in early- and late-onset preeclampsia.
Acta Obstet Gynecol Scand
; 93(5): 469-76, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24580069
ABSTRACT
OBJECTIVE:
To assess correlations between maternal serum levels of pro- and anti-angiogenic factors with uterine perfusion in women with early- compared with late-onset preeclampsia, and in healthy pregnant women.DESIGN:
Case-control study.SETTING:
Antenatal care clinic located within a hospital (São Bernardo do Campo, Brazil). POPULATION We enrolled 54 preeclamptic and 54 healthy control women who were coming for routine ultrasound at 28-36 weeks' gestation.METHODS:
All participants had uterine artery and umbilical Doppler studies and a blood sample to assess maternal serum levels of soluble fms-like tyrosine kinase-1, soluble endoglin, adiponectin and plasminogen activator inhibitor-1. All angiogenic factors were measured using enzyme-linked immunosorbent assay. MAIN OUTCOMEMEASURES:
Levels of pro- and anti-angiogenic factors in maternal serum, and uterine artery Doppler findings.RESULTS:
Concentrations of soluble fms-like tyrosine kinase-1 and soluble endoglin were significantly higher in preeclamptic than control women (p < 0.0001 and p < 0.0001, respectively), especially in those with early-onset (<34 weeks) preeclampsia. These two anti-angiogenic mediators were significantly correlated with increased uterine artery Doppler in the preeclamptic women. Plasminogen activator inhibitor-1 levels were significantly higher in preeclampsia (p = 0.03) but unrelated to uterine artery resistance. Adiponectin levels were similar in cases and controls, independent of body mass index and unrelated to uterine artery resistance.CONCLUSION:
Preeclamptic patients have increased soluble fms-like tyrosine kinase-1 and soluble endoglin serum levels and this increase is directly correlated with uterine artery resistance, especially in those with early-onset preeclampsia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Útero
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Resistência Vascular
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Fluxometria por Laser-Doppler
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Artéria Uterina
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Acta Obstet Gynecol Scand
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil